Cinnamon, the dried bark of Cinnamomum cassia Presl, is native to southern Vietnam and the eastern foothills of the Himalayas, it is widely used in North , Europe, South , asia-pacific, Middle East and Africa
Cinnamon is trough-shaped or roll-shaped, rough surface, easy to break, strong aroma; more than autumn after stripping dry, raw, mashed with time. Cinnamon is not only a spice, used as food cooking, cosmetics raw materials, but also a medicinal material, in the prevention and treatment of disease plays an important role. Cinnamon is one of the main ingredients in spices such as five-spice powder and thirteen-spice. Cinnamon taste sweet, can to a certain extent blood glucose and lipid regulation, protect heart health, anti-inflammatory and anti-bacterial, treatment of pain, improve gastrointestinal function, is since ancient times health treasures. Cinnamon contains the active ingredient cinnamaldehyde, is a natural food preservative, can help improve the antibacterial efficiency of food, vegetables, meat, dairy and starchy food has a certain freshness.
Cinnamon makes the sweet taste more sweet, mellow, can be made into cinnamon roll cinnamon coffee, cinnamon tea, cinnamon wine, mutton cinnamon soup.
Our cinnamon extract is 30% polyphenol.
The main polyphenols in cinnamon are flavonoids and their polymeric compounds, including catechins, epicatechin, cinnamon polyphenols A2, A3, A4, methylhydroxychalcone, epigallocatechin-3-gallate (EGCG) , proanthocyanidin-a, procyanidin-b (haploid, dimer, trimer, polymer) , condensation of tannin, ferulic acid, etc. . Polyphenol is the main component of cinnamon, with its pharmacological effects of increasing attention, its extraction process has been gradually optimized.
Study on pharmacological action of Cinnamomum cassia polyphenols
As the water-soluble part of Cinnamomum cassia, polyphenols have many pharmacological effects, it has pharmacological effects on the digestive system, cardiovascular system, immune system, endocrine system and central nervous system. It has anti-diabetic oxidation, anti-tumor and neuroprotective effects.
As the water-soluble part of Cinnamomum cassia, polyphenols have many pharmacological effects, it has pharmacological effects on the digestive system, cardiovascular system, immune system, endocrine system and central nervous system. It has anti-diabetic oxidation, anti-tumor and neuroprotective effects.
Anti-diabetic effect
After a large number of experiments by experts, confirmed the cinnamon polyphenols in vitro, animal experiments and clinical studies in hypoglycemic effect.
The possible hypoglycemic mechanisms of cinnamon polyphenols are:
Type 1 insulin action.
Type 1 insulin action.
The water extract of cinnamon can reduce the levels of two important regulators of hepatic gluconeogenesis, namely, glucose 6-phosphate enzyme (G-6-Pase) and phosphoenolpyruvate carboxykinase (Pepck)
2 increase insulin sensitivity and improve islet resistance
3 the activity of GSK-3B was decreased
Scavenge free radicals and fight Lipid peroxidation
2 increase insulin sensitivity and improve islet resistance
3 the activity of GSK-3B was decreased
Scavenge free radicals and fight Lipid peroxidation
Antioxidants
Polyphenols are highly reductive and can scavenge superoxide radicals, inhibit Lipid peroxidation and protect liver and kidney.
A number of experiments have shown that cinnamon polyphenols have antioxidant activity in animals and humans. The cinnamon aqueous extract was eluted with 5% acetonitrile and water containing 0.1 N acetic acid, and the eluting components at 14 and 19 min were able to inhibit collagen-stimulated ROS production in platelets.
The treatment with cinnamon polyphenols (0.3,0.6,1.2 g/kg/day) significantly reduced the levels of serum oxidative stress markers and the expression of iNOS and NF-B. In their study, Khuwijitjaru et al found a linear correlation between DPPH free radical scavenging capacity and total phenol content, providing strong evidence of the antioxidant capacity of Cinnamomum cassia polyphenols.
Anti-tumor
Natural plants have low toxicity and high efficacy. Nowadays, plant or herbal medicine extracts are widely studied to treat cancer. As a kind of medicinal plant, the polyphenol extract of Cinnamomum cassia has been studied on its anti-tumor effect and its mechanism at home and abroad.
Schoene, N. W. It was found that total polyphenols of Cinnamomum cassia inhibited the proliferation of acute lymphoblastic leukemia cells by regulating p38 MAPK and cyclin B1 signaling proteins, the process of cell cycle g 2/M phase was inhibited by destroying the phosphorylation/dephosphorylation in G 2/M phase.
At Schoenen. W. The results showed that the anti-tumor effect of the extract was related to the concentration and time, and this process was related to the effect of cinnamon water extract on promoting the apoptosis of tumor cells, cessation of cell cycle g 1 associated.
Neuroprotective effect
Swelling of the astrocyte is a component of cytotoxic brain edema in ischemic injury, and oxidative stress, mitochondrial dysfunction can all contribute to this swelling.
A large number of experiments have proved that plant polyphenols have antioxidant activity and play a protective role in ischemic injury and prevent the degenerative changes related to ischemic injury.
Our results suggest that polyphenols from Cinnamomum cassia can promote neuroprotection by up-regulating survival-affecting proteins, activating the mitogen-activated protein kinase pathway, and down-regulating Proinflammatory cytokine levels.
