|Product Code||C110103||Specification||Berberine Hydrochloride 95%|
|Extract Source||Phellodendron Chinense||Part Used||Bark|
|Extract Solvent||Ethanol / Water||Assay Method||HPLC|
|CAS NO.||633-65-8||Molecular Formula ||C20H18ClNO4|
|EINECS No. ||211-195-9||Molecular Weight ||371.81|
|Character||Light Yellow to Yellow Brown||Certification||ISO22000|
|HS Code||1302199099||Shelf Life||2 Years|
Melting point 204-206°C
Solubility in water SOLUBLE IN COLD WATER
Berberine Hydrochloride, also known as Flavopiridol Hydrochloride, has long been used in clinical practice as a purgative and antibacterial drug.
Berberine Hydrochloride is commonly used in the treatment of bacillary dysentery, acute gastroenteritis, chronic cholecystitis, conjunctivitis, purulent otitis media and other diseases, all of which have remarkable efficacy. It has also been found to have anti-arrhythmic effects. Berberine Hydrochloride has strong anti-tumor activity in vitro and in vivo and can induce B16 cell differentiation; it has synergistic effect with cytarabine hydrochloride in vitro. Antibacterial effect Berberine Hydrochloride has antibacterial effect on Streptococcus haemolyticus, Staphylococcus aureus, gonococcus and Bacillus fever and Shigella dysenteriae, and has enhanced phagocytosis of white blood cells. The hydrochloride of Berberine Hydrochloride(commonly known as xanthin hydrochloride) has been widely used in the treatment of gastroenteritis and bacterial dysentery, etc. It is also effective in tuberculosis, scarlet fever, acute tonsillitis and respiratory tract infections. Berberine Hydrochloride has a wide antibacterial spectrum and has in vitro antibacterial effects on a variety of gram-positive and negative bacteria, including Streptococcus haemolyticus, Staphylococcus aureus, Vibrio cholerae. It has strong inhibitory effect on meningococcus, Shigella dysenteriae, typhoid bacillus, diphtheria bacillus, etc. It is bacteriostatic at low concentration and bactericidal at high concentration. It also has some inhibitory effect on influenza virus, amoeba, leptospira and some skin fungi. In vitro experiments have confirmed that flavopiridol can enhance the phagocytosis of leukocytes and hepatic reticuloendothelial system. Dysentery bacillus, Streptococcus hemolyticus, Staphylococcus aureus, etc. are very easy to develop resistance to this product. It has no cross-resistance with penicillin and streptomycin.
Process Flow Chart of Berberine Hydrochloride
Application of Berberine Hydrochloride
Food, Health Care, Daily Necessities, Cosmetics, Functional Drink.
Q1: What's the difference between herb extract and powder?
A: The extract is a concentrated powder form of raw material. The herb extract's procedure flow is wash, extraction, concentration, purification, drying, grinding, sieving, package. The herb powder is just a powder form of the herb. The procedure flow is wash, drying, grinding, sieving, package.
Q2: What's the extract solvent used in the procedure?
A: The extract solvent is always depending on the active ingredient in the raw material, regulation and customers' requirement. The solvents mostly used for extraction are water and ethanol. Even the solvent other than water used in the procedure, the solvent residue in the extract product also can conform with ICH Q3CR5.
Q3: Is there any other ingredient used in the product?
A: It depends. For product which is hard to be dried, we need to add some maltodextrin into the extraction solution before drying. The maltodextrin we used is food-class carrier, from non-GMO corn. We can share customer with the ingredient composition table.
Q4: How to make sure the quality of the product?
A: Firstly, every batch finish product must be tested and qualified before delivery. We can send a specification sheet or CoA for confirmation. The HPLC chromatography graph also can be provided. Secondly, we can provide pre-ship sample to customer for quality confirmation.
Q5: Can you develop a new product for us?
A: Yes, we can. We have independent R&D dept, who is able to update the procedure parameters of our main products and develop the procedure of new product. For more information, please contact us directly.
Q6: Can you offer this in capsules or tablets as well?
A: Yes, we have related equipment for preparation of finish product, like tablet, capsule and granule. Kindly contact with us for details.
Q7: What is the MOQ?
A: For most of the products we already have in stock, the MOQ is 1kg. If the product is a new specification and need to be produced from raw material, the MOQ depends.
Q8: Is there any discount?
A: Yes, for larger quantity or better payment period, we can support with better price.
Q9: How about delivery time?
A: For most products, the product can be sent out from factory in 5days. If we don't have inventory, the product need to produced from raw material, the ordinary period is 20-25days.
Q10: How do you treat with quality complaint?
A: We will always be responsible for the quality of our products. If there's a complaint, we will first assist customers to solve the most direct needs.
Secondly, we have SOP for quality complaint. QA will investigate the problem, after that we'll give customer a formal feedback about the cause of the quality issue and related precautions for this problem.